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KMID : 0379520050210040319
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한국독성학회지
2005 Volume.21 No. 4 p.319 ~ p.323
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Systemic Availability and Pharmacokinetics of Surfactin, a Lipopeptide Produced by Bacillus subtilis BC1212 in Rats
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Lim Jong-Hwan
Kim Myoung-Seok
Park Byung-Kwon
Hwang Youn-Hwan
Hwang Mi-Hyun
Park Seung-Chun
Yun Hyo-In
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Abstract
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The aim of the present study was to evaluate systemic bioavailability of surfactin and to determine its pharmacokinetic profiles. The stability of surfactin to pH, temperature and protease was evaluated. Surfactin was resistant to high temperature, a wide range of pH and the action of hydrolytic enzymes. The pharmacokinetic natures of surfactin which were shown the short half-life, rapid clearance and poor bioavailability. The results of study should provide preliminary data of surfactin for further dose-finding studies and for the design of application forms. It is also be important to a context of the safety of surfactin.
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KEYWORD
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Surfactin, Bacillus subtilis, Pharmacokinetics, Bioavailability, Stability
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